Publications

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Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells

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METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation

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Dystrophic mdx mouse myoblasts exhibit elevated ATP/UTP-evoked metabotropic purinergic responses and alterations in calcium signalling

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SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

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Phosphorylation of histone H4T80 triggers DNA damage checkpoint recovery

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Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway

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Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

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A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

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RNA binding by the histone methyltransferases Set1 and Set2

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A Chemical Probe for the ATAD2 Bromodomain

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Discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition

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Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy

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The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31

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Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

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Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification

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BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms

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The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells

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Human RNA methyltransferase BCDIN3D regulates microRNA processing

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Three distinct patterns of histone H3Y41 phosphorylation mark active genes

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Deciphering c-MYC-regulated genes in two distinct tissues

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

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Nucleosome-interacting proteins regulated by DNA and histone methylation

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Origins and functional impact of copy number variation in the human genome

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Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

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