Publications | UoP Bioinformatics Group

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells

METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation

Dystrophic mdx mouse myoblasts exhibit elevated ATP/UTP-evoked metabotropic purinergic responses and alterations in calcium signalling

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

Phosphorylation of histone H4T80 triggers DNA damage checkpoint recovery

Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

RNA binding by the histone methyltransferases Set1 and Set2

A Chemical Probe for the ATAD2 Bromodomain

Discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition

Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy

The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31

Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification

BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms

The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells

Human RNA methyltransferase BCDIN3D regulates microRNA processing

Three distinct patterns of histone H3Y41 phosphorylation mark active genes

Deciphering c-MYC-regulated genes in two distinct tissues

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Nucleosome-interacting proteins regulated by DNA and histone methylation

Origins and functional impact of copy number variation in the human genome

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls